Source: Ministry of Science and Technology

Source: Ministry of Science and Technology

Recently, the 863 program project "Research and Development of High Strength and Toughness Porous Titanium Artificial Bone Materials (2015AA033702)" undertaken by the Institute of Metals of the Chinese Academy of Sciences and other units passed the technical acceptance. The high-strength and tough porous titanium alloy artificial bone material developed in this project provides a new approach for solving the clinical treatment difficulties of large-scale bone defect repair in the future.

Bone defects are common diseases in orthopedics and maxillofacial surgery, caused by trauma, infection, tumor resection, etc. The repair of large bone defects is currently a difficult problem in clinical treatment. This project has broken through the structural design and precise preparation technologies of new high-strength and tough porous titanium alloys, and combined with titanium alloy electron beam additive manufacturing technology, barium titanate piezoelectric ceramic in-situ preparation surface treatment technology, and in vitro ultrasound clinical treatment technology, developed porous titanium alloy artificial bone materials that meet the requirements of bone tissue repair.

At present, the porous titanium alloy artificial bone material developed in this project has passed the biocompatibility test; The porous orthopedic products developed, such as intervertebral fusion devices and femoral head support rods, have completed animal experimental evaluations and significantly improved the repair efficiency of defective bone tissue (≥ 20%) compared to the control group; The acetabular cup and porous interbody fusion device, which mimic the surface structure of bone trabeculae, have passed the registration inspection of the National Medical Products Administration and entered clinical trial research.

Bone repair biomaterials are a key research direction supported in biomedical materials. The successful research and development of a new type of high-strength and tough porous titanium alloy artificial bone repair material has laid a solid foundation for China's development of bone repair biomaterials and related instrument industries with independent intellectual property rights.